DGKZ

Identifiers

DGKZ, DAGK5, DAGK6, DGK-ZETA, hDGKzeta, diacylglycerol kinase zeta

External IDs

MGI: 1278339 HomoloGene: 37831 GeneCards: DGKZ

Gene ontology
Molecular function	• transferase activity • nucleotide binding • lipid kinase activity • metal ion binding • protein C-terminus binding • protein binding • ATP binding • kinase activity • diacylglycerol kinase activity • NAD+ kinase activity
Cellular component	• membrane • plasma membrane • nucleus • lamellipodium • cytoplasm • nuclear speck
Biological process	• GO:0007242 intracellular signal transduction • platelet activation • protein kinase C-activating G-protein coupled receptor signaling pathway • mitotic G1 DNA damage checkpoint • cell migration • negative regulation of mitotic cell cycle • glycerolipid metabolic process • phosphorylation • diacylglycerol metabolic process • lipid phosphorylation • metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8525


104418

Ensembl


ENSG00000149091


ENSMUSG00000040479

UniProt


Q13574


Q80UP3

RefSeq (mRNA)

NM_001105540 NM_001199266 NM_001199267 NM_001199268 NM_003646
NM_201532 NM_201533


NM_001166597 NM_138306

RefSeq (protein)

NP_001099010 NP_001186195 NP_001186196 NP_001186197 NP_003637
NP_963290 NP_963291


NP_612179.2 NP_001160069 NP_612179

Location (UCSC)

Chr 11: 46.33 – 46.38 Mb

Chr 2: 91.93 – 91.98 Mb

PubMed search

NM_001166597
NM_138306

NP_963290
NP_963291

NP_612179.2
NP_001160069
NP_612179

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

DGKZ has been shown to interact with P110α.

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