DLG1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1PDR, 2M3M, 2OQS, 2X7Z, 3RL7, 3RL8, 3W9Y, 4AMH, 4G69

Identifiers

Aliases

DLG1, DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, B130052P05Rik, E-dlg/SAP97, mKIAA4187, discs large homolog 1, scribble cell polarity complex component, discs large MAGUK scaffold protein 1

External IDs

MGI: 107231 HomoloGene: 20869 GeneCards: DLG1

Gene ontology
Molecular function	• phosphatase binding • phosphoprotein phosphatase activity • ion channel binding • cytoskeletal protein binding • protein C-terminus binding • ionotropic glutamate receptor binding • kinase binding • mitogen-activated protein kinase kinase binding • guanylate kinase activity • protein binding • protein complex scaffold • protein kinase binding • L27 domain binding • ligand-gated ion channel activity • potassium channel regulator activity • cadherin binding
Cellular component	• cytoplasm • cytosol • postsynaptic membrane • membrane • cell-cell junction • bicellular tight junction • node of Ranvier • synapse • perinuclear region of cytoplasm • cytoplasmic side of plasma membrane • microtubule • nucleus • cell projection membrane • membrane raft • ionotropic glutamate receptor complex • extracellular exosome • Golgi apparatus • lateral plasma membrane • intercalated disc • neuromuscular junction • myelin sheath abaxonal region • lateral loop • endoplasmic reticulum membrane • basal lamina • MPP7-DLG1-LIN7 complex • sarcolemma • postsynaptic density • cell junction • basolateral plasma membrane • plasma membrane • endoplasmic reticulum • immunological synapse
Biological process	• embryonic skeletal system morphogenesis • ureteric bud development • positive regulation of actin filament polymerization • positive regulation of potassium ion transport • negative regulation of p38MAPK cascade • amyloid precursor protein metabolic process • tissue morphogenesis • reproductive structure development • membrane raft organization • hard palate development • endothelial cell proliferation • smooth muscle tissue development • negative regulation of epithelial cell proliferation • regulation of sodium ion transmembrane transport • astral microtubule organization • actin filament organization • mitotic cell cycle checkpoint • receptor clustering • positive regulation of establishment of protein localization to plasma membrane • establishment or maintenance of cell polarity • negative regulation of T cell proliferation • branching involved in ureteric bud morphogenesis • regulation of myelination • cortical microtubule organization • establishment or maintenance of epithelial cell apical/basal polarity • viral process • T cell cytokine production • T cell activation • peristalsis • receptor localization to synapse • single organismal cell-cell adhesion • negative regulation of protein kinase B signaling • regulation of NIK/NF-kappaB signaling • negative regulation of transcription from RNA polymerase II promoter • nervous system development • regulation of cell shape • establishment of centrosome localization • immunological synapse formation • cortical actin cytoskeleton organization • protein localization • lens development in camera-type eye • cellular protein complex localization • bicellular tight junction assembly • positive regulation of cell proliferation • negative regulation of ERK1 and ERK2 cascade • activation of protein kinase activity • negative regulation of mitotic cell cycle • regulation of membrane potential • protein localization to plasma membrane • GDP metabolic process • ion transmembrane transport • protein dephosphorylation • GMP metabolic process • chemical synaptic transmission • regulation of ventricular cardiac muscle cell action potential • regulation of potassium ion import • regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • regulation of potassium ion export across plasma membrane
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1739


13383

Ensembl


ENSG00000075711


ENSMUSG00000022770

UniProt


Q12959


Q811D0

RefSeq (mRNA)

NM_001098424 NM_001204386 NM_001204387 NM_001204388 NM_001290983
NM_004087


NM_001252433 NM_001252434 NM_001252435 NM_001252436 NM_007862

RefSeq (protein)

NP_001091894 NP_001191315 NP_001191316 NP_001191317 NP_001277912
NP_004078

NP_001239362.1 NP_001239363.1 NP_001239364.1 NP_031888.2 NP_001239362
NP_001239363 NP_001239364 NP_001239365 NP_031888

Location (UCSC)

Chr 3: 197.04 – 197.3 Mb

Chr 16: 31.66 – 31.87 Mb

PubMed search

1PDR, 2M3M, 2OQS, 2X7Z, 3RL7, 3RL8, 3W9Y, 4AMH, 4G69

NM_001252433
NM_001252434
NM_001252435
NM_001252436
NM_007862

NP_004078

...
Wikipedia