DLX1

DLX1
Identifiers
Aliases	DLX1, Dlx, Dlx-1, distal-less homeobox 1
External IDs	MGI: 94901 HomoloGene: 22558 GeneCards: DLX1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • chromatin binding • protein binding Cellular component • nucleus Biological process • negative regulation of neuron apoptotic process • cerebral cortex GABAergic interneuron differentiation • proximal/distal pattern formation • cell differentiation • regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • embryonic skeletal system development • multicellular organism development • odontogenesis of dentin-containing tooth • cerebral cortex GABAergic interneuron fate commitment • negative regulation of oligodendrocyte differentiation • forebrain neuron differentiation • hippocampus development • subpallium development • negative regulation of Notch signaling pathway • positive regulation of cell differentiation • negative regulation of photoreceptor cell differentiation • positive regulation of amacrine cell differentiation • negative regulation of transcription from RNA polymerase II promoter • negative regulation of BMP signaling pathway • positive regulation of transcription from RNA polymerase II promoter • cellular response to transforming growth factor beta stimulus • cellular response to BMP stimulus • negative regulation of cellular response to transforming growth factor beta stimulus • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1745	13390
Ensembl	ENSG00000144355	ENSMUSG00000041911
UniProt	P56177	Q64317
RefSeq (mRNA)	NM_001038493 NM_178120	NM_010053
RefSeq (protein)	NP_001033582 NP_835221	NP_034183.1 NP_034183
Location (UCSC)	Chr 2: 172.08 – 172.09 Mb	Chr 2: 71.53 – 71.53 Mb
PubMed search

1745

13390

ENSG00000144355

ENSMUSG00000041911

P56177

Q64317

NM_001038493
NM_178120

NM_010053

NP_001033582
NP_835221

NP_034183.1
NP_034183

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.

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