DRAP1

DRAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JFI
Identifiers
Aliases	DRAP1, NC2-alpha, DR1 associated protein 1
External IDs	MGI: 1913806 HomoloGene: 4703 GeneCards: DRAP1
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 65,919,257 bp End 65,921,561 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 5,422,805 bp End 5,424,979 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein heterodimerization activity • protein binding • transcription factor activity, sequence-specific DNA binding • transcription corepressor activity • DNA binding • identical protein binding Cellular component • nucleus Biological process • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10589	66556
Ensembl	ENSG00000175550	ENSMUSG00000024914
UniProt	Q14919	Q9D6N5
RefSeq (mRNA)	NM_006442	NM_001291080 NM_024176
RefSeq (protein)	NP_006433	NP_001278009 NP_077138
Location (UCSC)	Chr 11: 65.92 – 65.92 Mb	Chr 11: 5.42 – 5.42 Mb
PubMed search

1JFI

10589

66556

ENSG00000175550

ENSMUSG00000024914

Q14919

Q9D6N5

NM_006442

NM_001291080
NM_024176

NP_006433

NP_001278009
NP_077138

Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.

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