David Kalergis (born December 9, 1948) is an American life sciences entrepreneur and the Co-founder and Chief Executive Officer of Diffusion Pharmaceuticals Inc, a Charlottesville, Virginia, U.S.-based biotechnology and pharmaceutical company. He co-founded the company in 2001 with American chemical engineer John L. Gainer. Kalergis became Diffusion's CEO in 2004, a position in which he has drawn extensively on his career in law, business, and clinical trials implementation. Under Kalergis’ leadership, Diffusion Pharmaceuticals has been cited for advancing improved cancer treatments and is currently conducting multicenter clinical trials of a novel therapeutic for brain cancers, including glioblastoma multiforme.
Kalergis received a B.A. degree in Psychology in 1970 and J.D. and M.B.A. Degrees in 1982 from the University of Virginia. He subsequently worked with the New York-based law firm Dewey, Ballantine, Bushby, Palmer & Wood, maintaining that association until 1986, when he became President and General Counsel of Designs Import/Export, Ltd. From 1991 to 1997, he was Consultant, Director of Business Development, and General Counsel to the contract research organization Pharmaceutical Research Associates (PRA), Inc. While with PRA, he was involved in numerous pharmaceutical development projects through the pre-clinical, clinical, and post-marketing stages.
In 1998 Kalergis was appointed Director of University of Virginia Gateway, a program to establish stronger ties between industry and academia, particularly in the area of life sciences. His efforts have been cited in advancing relationships between the high-technology business and academic sectors, both regionally and internationally. It was through his association with the University of Virginia that Kalergis met Gainer, who was at that time a Professor of Chemical Engineering, leading to their collaboration in the founding of Diffusion Pharmaceuticals.