DcR3

TNFRSF6B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3K51, 3MHD, 3MI8, 4J6G, 4KGG, 4KGQ, 4MSV
Identifiers
Aliases	TNFRSF6B, DCR3, DJ583P15.1.1, M68, M68E, TR6, tumor necrosis factor receptor superfamily member 6b, TNF receptor superfamily member 6b
External IDs	HomoloGene: 48242 GeneCards: TNFRSF6B
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.33 Start 63,696,668 bp End 63,698,684 bp
Gene ontology Molecular function • protein binding • tumor necrosis factor-activated receptor activity • receptor activity Cellular component • extracellular region • integral component of plasma membrane • extracellular space Biological process • multicellular organism development • apoptotic signaling pathway • response to lipopolysaccharide • inflammatory response • tumor necrosis factor-mediated signaling pathway • negative regulation of apoptotic process • regulation of cell proliferation • immune response • apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8771	n/a
Ensembl	ENSG00000243509	n/a
UniProt	O95407	n/a
RefSeq (mRNA)	NM_032945 NM_003823	n/a
RefSeq (protein)	NP_003814	n/a
Location (UCSC)	Chr 20: 63.7 – 63.7 Mb	n/a
PubMed search		n/a

3K51, 3MHD, 3MI8, 4J6G, 4KGG, 4KGQ, 4MSV

8771

n/a

ENSG00000243509

n/a

O95407

n/a

NM_032945
NM_003823

n/a

NP_003814

n/a

Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis.

Dcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database.

The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.

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