Death receptor 4

TNFRSF10A
Identifiers
Aliases	TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10a, TNF receptor superfamily member 10a
External IDs	MGI: 1341090 HomoloGene: 129806 GeneCards: TNFRSF10A
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.3 Start 23,190,452 bp End 23,225,126 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D2 Start 69,767,472 bp End 69,784,403 bp
Gene ontology Molecular function • TRAIL binding • transcription factor binding • protease binding • protein binding • tumor necrosis factor-activated receptor activity • death receptor activity • receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • intracellular Biological process • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • activation of NF-kappaB-inducing kinase activity • TRAIL-activated apoptotic signaling pathway • multicellular organism development • cell surface receptor signaling pathway • response to lipopolysaccharide • cellular response to mechanical stimulus • regulation of cell proliferation • immune response • regulation of extrinsic apoptotic signaling pathway via death domain receptors • inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • extrinsic apoptotic signaling pathway via death domain receptors • signal transduction • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • extrinsic apoptotic signaling pathway • tumor necrosis factor-mediated signaling pathway • apoptotic process • leukocyte migration • regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8797	21933
Ensembl	ENSG00000104689	ENSMUSG00000022074
UniProt	O00220	Q9QZM4
RefSeq (mRNA)	NM_003844	NM_020275
RefSeq (protein)	NP_003835	NP_064671
Location (UCSC)	Chr 8: 23.19 – 23.23 Mb	Chr 8: 69.77 – 69.78 Mb
PubMed search

8797

21933

ENSG00000104689

ENSMUSG00000022074

O00220

Q9QZM4

NM_003844

NM_020275

NP_003835

NP_064671

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis.

Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

TNFRSF10A has been shown to interact with DAP3.

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Wikipedia