Delta-9 desaturase

SCD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZYO
Identifiers
Aliases	SCD, FADS5, MSTP008, SCD1, SCDOS, hSCD1, stearoyl-CoA desaturase (delta-9-desaturase), stearoyl-CoA desaturase
External IDs	OMIM: 604031 MGI: 98239 HomoloGene: 74538 GeneCards: SCD
Gene location (Human) Chr. Chromosome 10 (human) Band No data available Start 100,347,124 bp End 100,364,834 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band No data available Start 44,394,451 bp End 44,407,709 bp
Gene ontology Molecular function • iron ion binding • stearoyl-CoA 9-desaturase activity • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water • metal ion binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • nucleolus Biological process • unsaturated fatty acid biosynthetic process • fatty acid biosynthetic process • oxidation-reduction process • fatty acid metabolic process • lipid metabolic process • regulation of cholesterol biosynthetic process • fatty-acyl-CoA biosynthetic process • monounsaturated fatty acid biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6319	20249
Ensembl	ENSG00000099194	ENSMUSG00000037071
UniProt	O00767	P13516
RefSeq (mRNA)	NM_005063	NM_009127
RefSeq (protein)	NP_005054	NP_033153
Location (UCSC)	Chr 10: 100.35 – 100.36 Mb	Chr 10: 44.39 – 44.41 Mb
PubMed search

4ZYO

6319

20249

ENSG00000099194

ENSMUSG00000037071

O00767

P13516

NM_005063

NM_009127

NP_005054

NP_033153

Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. Oleate and palmitoleate are major components of membrane phospholipids, cholesterol esters and alkyl-diacylglycerol. In humans, the enzyme is encoded by the SCD gene.

Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. It is responsible for forming a double bond in Stearoyl-CoA. This is how the monounsaturated fatty acid oleic acid is produced from the saturated fatty acid stearic acid.

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Wikipedia