Denzil Holles, 1st Baron Holles PC (31 October 1599 – 17 February 1680) was an English statesman and writer, best known as one of the Five Members whose attempted unconstitutional arrest by King Charles I in the House of Commons of England in 1642 sparked the Civil War.
Holles was the third son of John Holles, 1st Earl of Clare (c. 1564–1637), by Anne, daughter of Sir Thomas Stanhope. The favourite son of his father and endowed with great natural abilities, Denzil Holles grew up under advantageous circumstances. Destined to become one of the most formidable antagonists of King Charles's arbitrary government, he had been Charles's childhood friend. The Earl of Clare was, however, no friend to the Stuart administration, being especially hostile to the Duke of Buckingham; and on the accession of Charles to the throne the king's offers of favour were rejected. In 1624 Holles was returned as Member of Parliament for Mitchell in Cornwall, replacing his brother John who chose to sit for another constituency. In 1628 he was elected MP for Dorchester. He had from the first a keen sense of the humiliations which attended the foreign policy of the Stuart kings. Writing to the Earl of Strafford, his brother-in-law, on 29 November 1629, he severely censures Buckingham's conduct of the expedition to the Isle of Ré; "since England was England," he declared, "it received not so dishonourable a blow"; and he joined in the demand for Buckingham's impeachment in 1628.