Diacylglycerol lipase
| diacylglycerol lipase, alpha | |
|---|---|
| Identifiers | |
| Symbol | DAGLA |
| Alt. symbols | C11orf11 |
| Entrez | 747 |
| HUGO | 1165 |
| RefSeq | NM_006133 |
| UniProt | Q9Y4D2 |
| Other data | |
| EC number | 3.1.1.- |
| Locus | Chr. 11 q12.3 |
| diacylglycerol lipase, beta | |
|---|---|
| Identifiers | |
| Symbol | DAGLB |
| Entrez | 221955 |
| HUGO | 28923 |
| RefSeq | NM_139179 |
| UniProt | Q8NCG7 |
| Other data | |
| EC number | 3.1.1.- |
| Locus | Chr. 7 p22.1 |
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.
Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.
The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.
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