Dihydropyrimidine dehydrogenase
| dihydropyrimidine dehydrogenase | |
|---|---|
| Identifiers | |
| Symbol | DPYD |
| Entrez | 1806 |
| HUGO | 3012 |
| OMIM | 274270 |
| RefSeq | NM_000110 |
| Other data | |
| EC number | 1.3.1.2 |
| Locus | Chr. 1 p22 |
| Dihydropyrimidine dehydrogenase (NADP(+)) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.2 | ||||||||
| CAS number | 9029-01-0 | ||||||||
| Alt. names | Dihydrothymine dehydrogenase | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| Search | |
|---|---|
| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur.
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