Donald Caspar
| Donald L. D. Caspar | |
|---|---|
| Born | January 8, 1927 |
| Other names | Don Caspar |
| Citizenship | American |
| Nationality | American |
| Fields | Structural biology |
| Institutions |
California Institute of Technology Florida State University Brandeis University Birkbeck, University of London King's College London |
| Alma mater |
Cornell University (BA) Yale University (PhD) |
| Thesis | The Radial Structure of Tobacco Mosaic Virus (1955) |
| Doctoral advisor | Ernest C. Pollard |
| Other academic advisors |
Max Delbrück Rosalind Franklin |
| Notable awards | Fellow of the Biophysical Society Award |
|
Website Florida State University page |
|
Donald L. D. Caspar (born January 8, 1927) is an American structural biologist (the very term he coined) known for his works on the structures of biological molecules, particularly of the tobacco mosaic virus. He is an emeritus professor of biological science at the Institute of Molecular Biophysics, Florida State University, and an emeritus professor of biology at the Rosenstiel Basic Medical Sciences Research Center, Brandeis University. He has made significant scientific contributions in virus biology, X-ray, neutron and electron diffraction, and protein plasticity.
Caspar completed his BA in physics from Cornell University in 1950. He joined Yale University from where he earned his PhD in biophysics in 1955. He was supervised by Ernest C. Pollard. His thesis was on the structure of tobacco mosaic virus (TMV) titled The Radial Structure of Tobacco Mosaic Virus. While waiting for his degree he worked under Max Delbrück at the California Institute of Technology as post doctoral student. He worked with James D. Watson, with whom he had close professional association throughout his career. After receiving his PhD, he went to England having been awarded a fellowship at King's College London under Rosalind Franklin and during 1955–1956 worked with her at Birkbeck College in London. Their meeting was fruitful both personally and professionally. He remained one of Franklin's closest friends during her brief lifetime. In 1956 he and Franklin published individual but complementary papers in March 10 issue of Nature, together showing that TMV was a hollow rod, rather than a solid structure as generally believed. They also demonstrated that RNA in TMV was wound along the inner surface of the hollow virus. He was not a particularly enthusiastic writer; as a result, Franklin had to write every word of his paper.
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