EBI3

EBI3
Identifiers
Aliases	EBI3, IL-27B, IL27B, Epstein-Barr virus induced 3, IL35B
External IDs	MGI: 1354171 HomoloGene: 4207 GeneCards: EBI3
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 4,229,498 bp End 4,237,531 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 D|17 29.08 cM Start 55,952,623 bp End 55,957,021 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine receptor activity • cytokine activity • interleukin-27 receptor binding • protein binding Cellular component • extracellular region • plasma membrane • membrane • extracellular space • endoplasmic reticulum lumen Biological process • T-helper 1 type immune response • T cell proliferation • humoral immune response • positive regulation of alpha-beta T cell proliferation • positive regulation of interferon-gamma biosynthetic process • interleukin-12-mediated signaling pathway • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10148	50498
Ensembl	ENSG00000105246	ENSMUSG00000003206
UniProt	Q14213	O35228
RefSeq (mRNA)	NM_005755	NM_015766
RefSeq (protein)	NP_005746	NP_056581
Location (UCSC)	Chr 19: 4.23 – 4.24 Mb	Chr 19: 55.95 – 55.96 Mb
PubMed search

10148

50498

ENSG00000105246

ENSMUSG00000003206

Q14213

O35228

NM_005755

NM_015766

NP_005746

NP_056581

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.

This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells. IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.

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