EPHA1

EPHA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K1K, 2K1L, 3HIL, 3KKA
Identifiers
Aliases	EPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH
External IDs	MGI: 107381 HomoloGene: 3835 GeneCards: EPHA1
Gene location (Human) Chr. Chromosome 7 (human) Band 7q34-q35 Start 143,390,289 bp End 143,408,892 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.1 Start 42,358,487 bp End 42,373,268 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • transmembrane-ephrin receptor activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • protein kinase binding • ephrin receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • somatic stem cell population maintenance • negative regulation of protein kinase activity • activation of GTPase activity • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell-matrix adhesion • positive regulation of cell migration • regulation of GTPase activity • positive regulation of angiogenesis • protein phosphorylation • cell surface receptor signaling pathway • negative regulation of cell migration • cell adhesion • angiogenesis • positive regulation of cell proliferation • protein autophosphorylation • peptidyl-tyrosine phosphorylation • substrate adhesion-dependent cell spreading • positive regulation of stress fiber assembly • ephrin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2041	13835
Ensembl	ENSG00000146904	ENSMUSG00000029859
UniProt	P21709	Q60750
RefSeq (mRNA)	NM_005232	NM_023580
RefSeq (protein)	NP_005223	NP_076069
Location (UCSC)	Chr 7: 143.39 – 143.41 Mb	Chr 7: 42.36 – 42.37 Mb
PubMed search

2K1K, 2K1L, 3HIL, 3KKA

2041

13835

ENSG00000146904

ENSMUSG00000029859

P21709

Q60750

NM_005232

NM_023580

NP_005223

NP_076069

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.

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Wikipedia