EPHA5

EPHA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R2P, 4ET7
Identifiers
Aliases	EPHA5, CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4, EPH receptor A5
External IDs	MGI: 99654 HomoloGene: 55824 GeneCards: EPHA5
Genetically Related Diseases
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • GPI-linked ephrin receptor activity • transmembrane-ephrin receptor activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • ephrin receptor activity Cellular component • integral component of membrane • rough endoplasmic reticulum • cell projection • membrane • plasma membrane • integral component of plasma membrane • axon • neuronal cell body • dendrite • perinuclear region of cytoplasm • external side of plasma membrane Biological process • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of actin cytoskeleton organization • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • regulation of GTPase activity • neuron development • nervous system development • protein phosphorylation • positive regulation of CREB transcription factor activity • peptidyl-tyrosine phosphorylation • hippocampus development • cAMP-mediated signaling • axon guidance • ephrin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2044	13839
Ensembl	ENSG00000145242	ENSMUSG00000029245
UniProt	P54756	Q60629
RefSeq (mRNA)	NM_001281765 NM_001281766 NM_001281767 NM_004439 NM_182472 NM_001318761	NM_007937
RefSeq (protein)	NP_001268694 NP_001268695 NP_001268696 NP_001305690 NP_004430 NP_872272	NP_031963.2 NP_031963
Location (UCSC)	Chr 4: 65.32 – 65.67 Mb	Chr 5: 84.05 – 84.42 Mb
PubMed search

2R2P, 4ET7

2044

13839

ENSG00000145242

ENSMUSG00000029245

P54756

Q60629

NM_001318761

NM_007937

NP_872272

NP_031963.2
NP_031963

EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene.

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

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