EPHA8

EPHA8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UCV, 1X5L, 3KUL
Identifiers
Aliases	EPHA8, EEK, EK3, HEK3, EPH receptor A8
External IDs	MGI: 109378 HomoloGene: 22436 GeneCards: EPHA8
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.12 Start 22,563,564 bp End 22,603,594 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D3 Start 136,929,419 bp End 136,956,816 bp
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • ephrin receptor activity • GPI-linked ephrin receptor activity Cellular component • integral component of membrane • endosome • cell projection • early endosome membrane • membrane • integral component of plasma membrane • plasma membrane • neuron projection Biological process • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • multicellular organism development • protein phosphorylation • cell adhesion • peptidyl-tyrosine phosphorylation • substrate-dependent cell migration • protein autophosphorylation • axon guidance • neuron projection development • regulation of cell adhesion • regulation of cell adhesion mediated by integrin • neuron remodeling • positive regulation of phosphatidylinositol 3-kinase activity • ephrin receptor signaling pathway • positive regulation of MAPK cascade • cellular response to follicle-stimulating hormone stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2046	13842
Ensembl	ENSG00000070886	ENSMUSG00000028661
UniProt	P29322	O09127
RefSeq (mRNA)	NM_001006943 NM_020526	NM_007939
RefSeq (protein)	NP_001006944 NP_065387	NP_031965
Location (UCSC)	Chr 1: 22.56 – 22.6 Mb	Chr 1: 136.93 – 136.96 Mb
PubMed search

1UCV, 1X5L, 3KUL

2046

13842

ENSG00000070886

ENSMUSG00000028661

P29322

O09127

NM_001006943
NM_020526

NM_007939

NP_001006944
NP_065387

NP_031965

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.

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Wikipedia