EPHB1

EPHB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJS, 2EAO, 3ZFX
Identifiers
Aliases	EPHB1, Ephb1, 9330129L11, AW488255, C130099E04Rik, Cek6, ENSMUSG00000074119, Elk, Elkh, Hek6, Net, EPHT2, EPH receptor B1, ELK, NET
External IDs	MGI: 1096337 HomoloGene: 20936 GeneCards: EPHB1
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.2 Start 134,597,801 bp End 135,260,467 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 101,922,128 bp End 102,354,693 bp
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • ephrin receptor activity • axon guidance receptor activity • transmembrane-ephrin receptor activity • protein complex binding Cellular component • integral component of membrane • endosome • cell projection • early endosome membrane • membrane • integral component of plasma membrane • extracellular region • dendrite • extracellular exosome • endoplasmic reticulum • cytosol • plasma membrane • axon • cytoplasm • filopodium tip • membrane raft Biological process • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • dendritic spine development • cell-substrate adhesion • regulation of JNK cascade • protein phosphorylation • cell adhesion • regulation of neuron death • regulation of ERK1 and ERK2 cascade • protein autophosphorylation • peptidyl-tyrosine phosphorylation • immunological synapse formation • axon guidance • optic nerve morphogenesis • central nervous system projection neuron axonogenesis • retinal ganglion cell axon guidance • ephrin receptor signaling pathway • camera-type eye morphogenesis • positive regulation of synapse assembly • dendritic spine morphogenesis • angiogenesis • skeletal muscle satellite cell activation • cranial nerve development • neurogenesis • establishment of cell polarity • detection of temperature stimulus involved in sensory perception of pain • cell chemotaxis • neural precursor cell proliferation • negative regulation of skeletal muscle satellite cell proliferation • negative regulation of satellite cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2047	270190
Ensembl	ENSG00000154928	ENSMUSG00000032537
UniProt	P54762	Q8CBF3
RefSeq (mRNA)	NM_004441	NM_001168296 NM_173447
RefSeq (protein)	NP_004432	NP_001161768 NP_775623
Location (UCSC)	Chr 3: 134.6 – 135.26 Mb	Chr 3: 101.92 – 102.35 Mb
PubMed search

2DJS, 2EAO, 3ZFX

2047

270190

ENSG00000154928

ENSMUSG00000032537

P54762

Q8CBF3

NM_004441

NM_001168296
NM_173447

NP_004432

NP_001161768
NP_775623

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

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Wikipedia