EPHB3

EPHB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P1I, 3ZFY
Identifiers
Aliases	EPHB3, ETK2, HEK2, TYRO6, EPH receptor B3, EK2
External IDs	MGI: 104770 HomoloGene: 20938 GeneCards: EPHB3
Gene ontology Molecular function • nucleotide binding • transmembrane receptor protein tyrosine kinase activity • protein kinase activity • kinase activity • ATP binding • transferase activity • protein tyrosine kinase activity • ephrin receptor activity Cellular component • extracellular region • dendrite • integral component of membrane • cell projection • membrane • cytosol • plasma membrane • integral component of plasma membrane Biological process • phosphorylation • peptidyl-tyrosine phosphorylation • nervous system development • multicellular organism development • regulation of cell-cell adhesion • protein phosphorylation • substrate adhesion-dependent cell spreading • transmembrane receptor protein tyrosine kinase signaling pathway • regulation of GTPase activity • protein autophosphorylation • angiogenesis • ephrin receptor signaling pathway • urogenital system development • axon guidance • axonal fasciculation • cell migration • corpus callosum development • thymus development • digestive tract morphogenesis • regulation of axonogenesis • positive regulation of synapse assembly • palate development • dendritic spine development • dendritic spine morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2049	13845
Ensembl	ENSG00000182580	ENSMUSG00000005958
UniProt	P54753	P54754
RefSeq (mRNA)	NM_004443	NM_010143
RefSeq (protein)	NP_004434	NP_034273
Location (UCSC)	Chr 3: 184.56 – 184.58 Mb	Chr 16: 21.2 – 21.22 Mb
PubMed search

3P1I, 3ZFY

2049

13845

ENSG00000182580

ENSMUSG00000005958

P54753

P54754

NM_004443

NM_010143

NP_004434

NP_034273

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

EPHB3 has been shown to interact with MLLT4 and RAS p21 protein activator 1.

...
Wikipedia