ERK5

MAPK7

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2Q8Y, 4B99, 4IC7, 4IC8, 4ZSJ, 4ZSL, 5BYZ, 5BYY, 4ZSG

Identifiers

MAPK7, BMK1, ERK4, ERK5, PRKM7, mitogen-activated protein kinase 7

External IDs

MGI: 1346347 HomoloGene: 2060 GeneCards: MAPK7

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17p11.2	Start	19,377,721 bp
Band	17p11.2	End	19,383,544 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11\|11 B2	Start	61,488,812 bp
Band	11\|11 B2	End	61,494,406 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • mitogen-activated protein kinase binding • kinase activity • protein binding • ATP binding • protein serine/threonine kinase activity • MAP kinase activity
Cellular component	• cytoplasm • cytosol • PML body • nucleoplasm • cell nucleus
Biological process	• cellular response to transforming growth factor beta stimulus • negative regulation of endothelial cell apoptotic process • cell differentiation • phosphorylation • negative regulation of cAMP catabolic process • negative regulation of ERK5 cascade • cellular response to laminar fluid shear stress • positive regulation of transcription from RNA polymerase II promoter in response to stress • cellular response to growth factor stimulus • negative regulation of apoptotic process • regulation of angiogenesis • negative regulation of response to cytokine stimulus • positive regulation of protein metabolic process • protein phosphorylation • negative regulation of MAP kinase activity • peptidyl-serine phosphorylation • cell cycle • negative regulation of cyclic-nucleotide phosphodiesterase activity • negative regulation of heterotypic cell-cell adhesion • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of inflammatory response • cAMP-mediated signaling • signal transduction • positive regulation of transcription from RNA polymerase II promoter • cellular response to hydrogen peroxide • MAPK cascade • axon guidance • negative regulation of calcineurin-NFAT signaling cascade
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


5598


23939


ENSG00000166484


ENSMUSG00000001034


Q13164


Q9WVS8

RefSeq (mRNA)


NM_002749 NM_139032 NM_139033 NM_139034

NM_001291033 NM_001291034 NM_001291035 NM_001291036 NM_001291037
NM_011841 NM_001361989

RefSeq (protein)


NP_002740 NP_620601 NP_620602 NP_620603

NP_001277962 NP_001277963 NP_001277964 NP_001277965 NP_001277966
NP_035971 NP_001348918

Location (UCSC)

Chr 17: 19.38 – 19.38 Mb

Chr 11: 61.49 – 61.49 Mb

PubMed search

2Q8Y, 4B99, 4IC7, 4IC8, 4ZSJ, 4ZSL, 5BYZ, 5BYY, 4ZSG

ENSG00000166484

ENSMUSG00000001034

NM_002749
NM_139032
NM_139033
NM_139034

NM_011841
NM_001361989

NP_002740
NP_620601
NP_620602
NP_620603

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Wikipedia

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