ERp57

PDIA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ALB, 2DMM, 2H8L, 3F8U
Identifiers
Aliases	PDIA3, protein disulfide isomerase family A, member 3, ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC, protein disulfide isomerase family A member 3
External IDs	MGI: 95834 HomoloGene: 68454 GeneCards: PDIA3
Gene location (Human) Chr. Chromosome 15 (human) Band No data available Start 43,746,392 bp End 43,773,279 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band No data available Start 121,413,775 bp End 121,438,687 bp
Gene ontology Molecular function • disulfide oxidoreductase activity • isomerase activity • protein binding • phospholipase C activity • cysteine-type endopeptidase activity • RNA binding • protein disulfide isomerase activity • peptide disulfide oxidoreductase activity Cellular component • endoplasmic reticulum lumen • focal adhesion • melanosome • myelin sheath • cell surface • endoplasmic reticulum • extracellular exosome • nucleus • phagocytic vesicle • recycling endosome membrane • extracellular space Biological process • protein import into nucleus • antigen processing and presentation of peptide antigen via MHC class I • protein folding in endoplasmic reticulum • cell redox homeostasis • response to endoplasmic reticulum stress • protein retention in ER lumen • protein folding • positive regulation of extrinsic apoptotic signaling pathway • signal transduction • oxidation-reduction process • proteolysis • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2923	14827
Ensembl	ENSG00000167004	ENSMUSG00000027248
UniProt	P30101	P27773
RefSeq (mRNA)	NM_005313	NM_007952
RefSeq (protein)	NP_005304	NP_031978
Location (UCSC)	Chr 15: 43.75 – 43.77 Mb	Chr 15: 121.41 – 121.44 Mb
PubMed search

2ALB, 2DMM, 2H8L, 3F8U

2923

14827

ENSG00000167004

ENSMUSG00000027248

P30101

P27773

NM_005313

NM_007952

NP_005304

NP_031978

Protein disulfide-isomerase A3 (PDIA3), also known as glucose-regulated protein, 58-kD (GRP58), is an isomerase enzyme. This protein localizes to the endoplasmic reticulum (ER) and interacts with lectin chaperones calreticulin and calnexin (CNX) to modulate folding of newly synthesized glycoproteins. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.

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Wikipedia