Endoglin

ENG

Identifiers

ENG, Eng, AI528660, AI662476, CD105, Endo, S-endoglin, END, HHT1, ORW1, endoglin

External IDs

MGI: 95392 HomoloGene: 92 GeneCards: ENG

Gene ontology
Molecular function	• type I transforming growth factor beta receptor binding • protein homodimerization activity • activin binding • transforming growth factor beta-activated receptor activity • transforming growth factor beta receptor, cytoplasmic mediator activity • galactose binding • glycosaminoglycan binding • BMP binding • protein binding • transforming growth factor beta binding • transmembrane signaling receptor activity • type II transforming growth factor beta receptor binding
Cellular component	• integral component of membrane • membrane • focal adhesion • receptor complex • endothelial microparticle • transforming growth factor beta receptor complex • external side of plasma membrane • cell surface • extracellular space
Biological process	• cell migration involved in endocardial cushion formation • response to hypoxia • regulation of transcription, DNA-templated • negative regulation of nitric-oxide synthase activity • negative regulation of protein autophosphorylation • venous blood vessel morphogenesis • cell motility • positive regulation of pathway-restricted SMAD protein phosphorylation • regulation of phosphorylation • extracellular matrix disassembly • positive regulation of systemic arterial blood pressure • wound healing • negative regulation of transcription from RNA polymerase II promoter • negative regulation of transforming growth factor beta receptor signaling pathway • BMP signaling pathway • negative regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of angiogenesis • negative regulation of endothelial cell proliferation • vasculogenesis • heart looping • heart development • regulation of cell adhesion • chronological cell aging • cell adhesion • negative regulation of cell migration • regulation of cell proliferation • angiogenesis • artery morphogenesis • central nervous system vasculogenesis • smooth muscle tissue development • positive regulation of BMP signaling pathway • branching involved in blood vessel morphogenesis • cell chemotaxis • transforming growth factor beta receptor signaling pathway • cell migration • detection of hypoxia • regulation of transforming growth factor beta receptor signaling pathway • positive regulation of gene expression • regulation of cardiac muscle cell apoptotic process • bone development • positive regulation of protein phosphorylation • endocardial cushion to mesenchymal transition • sprouting angiogenesis • response to corticosteroid • extracellular matrix constituent secretion • regulation of cell proliferation involved in heart morphogenesis • response to transforming growth factor beta • positive regulation of collagen biosynthetic process • cellular response to mechanical stimulus • outflow tract septum morphogenesis • epithelial to mesenchymal transition involved in endocardial cushion formation • endocardial cushion morphogenesis • cardiac ventricle morphogenesis • cardiac atrium morphogenesis • ventricular trabecula myocardium morphogenesis • negative regulation of gene expression • dorsal aorta morphogenesis • response to drug • positive regulation of transcription from RNA polymerase II promoter • atrial cardiac muscle tissue morphogenesis • vascular smooth muscle cell development • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of vascular smooth muscle cell differentiation • atrioventricular canal morphogenesis • regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE ENG 201808 s at fs.png

PBB GE ENG 201809 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


2022


13805


ENSG00000106991


ENSMUSG00000026814


P17813 Q96CG0


Q63961

RefSeq (mRNA)


NM_000118 NM_001114753 NM_001278138


NM_001146348 NM_001146350 NM_007932

RefSeq (protein)


NP_000109 NP_001108225 NP_001265067 NP_001108225.1 NP_001265067.1


NP_031958.2 NP_001139820 NP_001139822 NP_031958

Location (UCSC)

Chr 9: 127.82 – 127.85 Mb

Chr 2: 32.65 – 32.68 Mb

PubMed search

ENSG00000106991

ENSMUSG00000026814

NM_000118
NM_001114753
NM_001278138

NM_001146348
NM_001146350
NM_007932

NP_000109
NP_001108225
NP_001265067
NP_001108225.1
NP_001265067.1

NP_031958.2
NP_001139820
NP_001139822
NP_031958

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Wikipedia

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