Epoxide hydrolase 3

EPHX3

Identifiers

EPHX3, ABHD9, EH3, epoxide hydrolase 3

External IDs

MGI: 1919182 HomoloGene: 69386 GeneCards: EPHX3

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19p13.12	Start	15,226,919 bp
Band	19p13.12	End	15,233,435 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 B1	Start	32,183,770 bp
Band	17\|17 B1	End	32,189,549 bp

Gene ontology
Molecular function	• catalytic activity • hydrolase activity • epoxide hydrolase activity
Cellular component	• extracellular region • membrane • intracellular membrane-bounded organelle
Biological process	• epoxide metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79852


71932

Ensembl


ENSG00000105131


ENSMUSG00000037577

UniProt


Q9H6B9


Q3V1F8

RefSeq (mRNA)


NM_024794 NM_001142886


NM_001033163 NM_001347341

RefSeq (protein)


NP_001136358 NP_079070


NP_001028335 NP_001334270

Location (UCSC)

Chr 19: 15.23 – 15.23 Mb

Chr 19: 32.18 – 32.19 Mb

PubMed search

NM_024794
NM_001142886

NM_001033163
NM_001347341

NP_001136358
NP_079070

NP_001028335
NP_001334270

Epoxide hydrolase 3 (ABHD9, EH3, EPHX3), encoded by the EPHX3 gene, is the third defined isozyme in a set of epoxide hydrolase isozymes, i.e. the epoxide hydrolases. This set includes the Microsomal epoxide hydrolase (also termed epoxide hydrolase 1, EPHX1, mEH, and EH1); the epoxide hydrolase 2 (also termed soluble epoxide hydrolase, EPHX2, sEH and EH2); and the far less well defined enzymatically, epoxide hydrolase 4 (also termed ABHD7 and EH4). All four enzyme contain an Alpha/beta hydrolase fold suggesting that they have Hydrolysis activity. EH1, EH2, and EH3 have been shown to have such activity in that they add water to epoxides of unsaturated fatty acids to form vicinal cis (see cis-trans isomerism) products; the activity of EH4 has not been reported. The former three EH's differ in subcellular location, tissue expression patterns, substrate preferences, and thereby functions. These functions include limiting the biologically actions of certain fatty acid epoxides, increasing the toxicity of other fatty acid epoxides, and contributing to the metabolism of drugs and other xenobiotics.

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