Estradiol dipropionate

Estradiol dipropionate
Clinical data

Trade names	Agofollin, Di-Ovocyclin, Progynon DP
Synonyms	17β-Estradiol-3,17-dipropionate; Estra-1,3,5(10)-triene-3,17β-diol, 3,17β-dipropanoate
Routes of administration	Intramuscular
ATC code	None
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
CAS Number	113-38-2
PubChem CID	8225
ChemSpider	7932
UNII	NIG5418BXB
ChEMBL	CHEMBL1697791
ECHA InfoCard	100.003.660
Chemical and physical data
Formula	C₂₄H₃₂O₄
Molar mass	384.509 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(Oc1cc3c(cc1)[C@H]2CC[C@@]4([C@@H](OC(=O)CC)CC[C@H]4[C@@H]2CC3)C)CC
InChI InChI=1S/C24H32O4/c1-4-22(25)27-16-7-9-17-15(14-16)6-8-19-18(17)12-13-24(3)20(19)10-11-21(24)28-23(26)5-2/h7,9,14,18-21H,4-6,8,10-13H2,1-3H3/t18-,19-,20+,21+,24+/m1/s1 Key:JQIYNMYZKRGDFK-RUFWAXPRSA-N

Estradiol dipropionate (BAN, JAN) (brand names Agofollin, Di-Ovocyclin, Progynon DP, others) is a semisynthetic, steroidal estrogen that is or has been marketed in the United States and Europe. It is the 3,17β-dipropanoyl ester of estradiol. Along with estradiol benzoate, estradiol dipropionate was one of the first estradiol esters to be developed, having been patented in 1937, was assessed in clinical studies by 1939, and has been marketed by Schering as Progynon DP and Ciba Pharmaceutical Products as Di-Ovocylin since at least 1940. Relative to estradiol benzoate, estradiol dipropionate has enhanced and very prolonged effects. Prior to the development and introduction of estradiol valerate and estradiol cypionate in the 1950s, estradiol dipropionate and estradiol benzoate were the most widely used estradiol esters.

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