Estrogen-related receptor alpha

ESRRA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1XB7, 2PJL, 3D24, 3K6P
Identifiers
Aliases	ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1, estrogen related receptor alpha
External IDs	HomoloGene: 136738 GeneCards: ESRRA
Targeted by Drug
biochanin A, daidzein, genistein, XCT790
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • steroid hormone receptor activity • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • steroid binding • protein binding Cellular component • microtubule cytoskeleton • nucleoplasm • intercellular bridge • nucleus • fibrillar center Biological process • response to estradiol • regulation of transcription, DNA-templated • positive regulation of cellular response to insulin stimulus • mitochondrion organization • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • cartilage development • regulation of cell proliferation • regulation of osteoblast differentiation • regulation of osteoclast differentiation • regulation of ossification • transcription initiation from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • steroid hormone mediated signaling pathway • intracellular receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2101	n/a
Ensembl	ENSG00000173153	n/a
UniProt	P11474	n/a
RefSeq (mRNA)	NM_001282450 NM_001282451 NM_004451	n/a
RefSeq (protein)	NP_001269379 NP_001269380 NP_004442	n/a
Location (UCSC)	Chr 11: 64.31 – 64.32 Mb	n/a
PubMed search		n/a

1XB7, 2PJL, 3D24, 3K6P

2101

n/a

ENSG00000173153

n/a

P11474

n/a

NM_001282450
NM_001282451
NM_004451

n/a

NP_001269379
NP_001269380
NP_004442

n/a

Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is encoded by the ESRRA (Estrogen Related Receptor Alpha) gene. ERRα was originally cloned by DNA sequence homology to the estrogen receptor alpha (ERα, NR3A1), but subsequent ligand binding and reporter-gene transfection experiments demonstrated that estrogens did not regulate ERRα. Currently, ERRα is considered an orphan nuclear receptor.

ERRα has wide tissue distribution but it is most highly expressed in tissues that preferentially use fatty acids as energy sources such as kidney, heart, cerebellum, intestine, and skeletal muscle. Recently, ERRα has been detected in normal adrenal cortex tissues, in which its expression is possibly related to adrenal development, with a possible role in fetal adrenal function, in DHEAS production in adrenarche, and also in steroid production of post-adrenarche/adult life.

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