F13B

Identifiers

Aliases

F13B, FXIIIB, coagulation factor XIII B chain

External IDs

MGI: 88379 HomoloGene: 1512 GeneCards: F13B

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2165


14060

Ensembl


ENSG00000143278


ENSMUSG00000026368

UniProt


P05160


Q07968

RefSeq (mRNA)


NM_001994


NM_031164

RefSeq (protein)


NP_001985


NP_112441

Location (UCSC)

Chr 1: 197.04 – 197.07 Mb

Chr 1: 139.5 – 139.52 Mb

PubMed search

Coagulation factor XIII B chain is a protein that in humans is encoded by the F13B gene.

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

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Wikipedia