FARP1

FARP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H6Y
Identifiers
Aliases	FARP1, CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1
External IDs	MGI: 2446173 HomoloGene: 38098 GeneCards: FARP1
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • cytoskeletal protein binding • Rho guanyl-nucleotide exchange factor activity Cellular component • cytosol • cell projection • membrane • filopodium • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • dendritic spine • synapse • cell junction • dendrite • neuron projection • cytoskeleton • cytoplasm Biological process • dendrite morphogenesis • negative regulation of phosphatase activity • multicellular organism development • synapse assembly • regulation of Rho protein signal transduction • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10160	223254
Ensembl	ENSG00000152767	ENSMUSG00000025555
UniProt	Q9Y4F1	F8VPU2
RefSeq (mRNA)	NM_001001715 NM_001286839 NM_005766	NM_134082
RefSeq (protein)	NP_001001715 NP_001273768 NP_005757	NP_598843
Location (UCSC)	Chr 13: 98.14 – 98.46 Mb	Chr 14: 121.04 – 121.28 Mb
PubMed search

4H6Y

10160

223254

ENSG00000152767

ENSMUSG00000025555

Q9Y4F1

F8VPU2

NM_001001715
NM_001286839
NM_005766

NM_134082

NP_001001715
NP_001273768
NP_005757

NP_598843

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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