FGD2

FGD2
Identifiers
Aliases	FGD2, ZFYVE4, FYVE, RhoGEF and PH domain containing 2
External IDs	MGI: 1347084 HomoloGene: 8438 GeneCards: FGD2
Gene ontology Molecular function • phosphatidylinositol phosphate binding • metal ion binding • small GTPase binding • protein binding • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • endosome • Golgi apparatus • cell projection • early endosome membrane • membrane • ruffle • plasma membrane • ruffle membrane • early endosome • cytoskeleton • nucleus • lamellipodium Biological process • positive regulation of JUN kinase activity • regulation of GTPase activity • filopodium assembly • positive regulation of GTPase activity • cytoskeleton organization • regulation of cell shape • positive regulation of apoptotic process • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221472	26382
Ensembl	ENSG00000146192	ENSMUSG00000024013
UniProt	Q7Z6J4	Q8BY35
RefSeq (mRNA)	NM_173558	NM_001159538 NM_013710
RefSeq (protein)	NP_775829	NP_001153010 NP_038738
Location (UCSC)	Chr 6: 37.01 – 37.03 Mb	Chr 17: 29.36 – 29.38 Mb
PubMed search

221472

26382

ENSG00000146192

ENSMUSG00000024013

Q7Z6J4

Q8BY35

NM_173558

NM_001159538
NM_013710

NP_775829

NP_001153010
NP_038738

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

It is a member of the FYVE, RhoGEF and PH domain containing family.

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Wikipedia