FLRT1

FLRT1
Identifiers
Aliases	FLRT1, SPG68, fibronectin leucine rich transmembrane protein 1
External IDs	MGI: 3026647 HomoloGene: 40864 GeneCards: FLRT1
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 64,103,188 bp End 64,119,173 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 7,092,014 bp End 7,105,729 bp
Gene ontology Molecular function • protein binding, bridging • signal transducer activity, downstream of receptor • fibroblast growth factor receptor binding • protein kinase inhibitor activity Cellular component • cytoplasm • integral component of membrane • cell projection • endoplasmic reticulum membrane • membrane • cell-cell junction • focal adhesion • proteinaceous extracellular matrix • integral component of plasma membrane • neuronal cell body membrane • extracellular region • cell junction • endoplasmic reticulum • perinuclear region of cytoplasm • neuron projection terminus • cytoplasmic vesicle membrane • cytoplasmic vesicle • plasma membrane • extracellular space Biological process • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • dendrite development • neuron projection extension • multicellular organism development • cell adhesion • negative regulation of JAK-STAT cascade • positive regulation of synapse assembly • fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23769	396184
Ensembl	ENSG00000126500	ENSMUSG00000047787
UniProt	Q9NZU1	Q6RKD8
RefSeq (mRNA)	NM_013280	NM_201411
RefSeq (protein)	NP_037412	NP_958813
Location (UCSC)	Chr 11: 64.1 – 64.12 Mb	Chr 11: 7.09 – 7.11 Mb
PubMed search

23769

396184

ENSG00000126500

ENSMUSG00000047787

Q9NZU1

Q6RKD8

NM_013280

NM_201411

NP_037412

NP_958813

Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene.

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

...
Wikipedia