FLT1

FLT1

Protein FLT1 PDB 1flt.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3

Identifiers

FLT1, FLT, FLT-1, VEGFR-1, VEGFR1, fms related tyrosine kinase 1

External IDs

MGI: 95558 HomoloGene: 134179 GeneCards: FLT1

Genetically Related Diseases

coronary artery disease

Targeted by Drug

cediranib, linifanib, motesanib, nintedanib, pazopanib, semaxanib, tivozanib, vatalanib

Gene ontology
Molecular function	• vascular endothelial growth factor-activated receptor activity • transferase activity • nucleotide binding • protein kinase activity • VEGF-B-activated receptor activity • placental growth factor-activated receptor activity • kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • VEGF-A-activated receptor activity • protein tyrosine kinase activity • ATP binding • growth factor binding
Cellular component	• cytoplasm • integral component of membrane • endosome • focal adhesion • membrane • receptor complex • integral component of plasma membrane • extracellular region • extracellular space • plasma membrane • actin cytoskeleton
Biological process	• positive regulation of vascular endothelial growth factor receptor signaling pathway • cell differentiation • blood vessel morphogenesis • vascular endothelial growth factor receptor-1 signaling pathway • positive regulation of MAP kinase activity • monocyte chemotaxis • positive regulation of phospholipase C activity • transmembrane receptor protein tyrosine kinase signaling pathway • vascular endothelial growth factor signaling pathway • phosphorylation • positive regulation of angiogenesis • positive regulation of phosphatidylinositol 3-kinase activity • multicellular organism development • chemotaxis • protein phosphorylation • vascular endothelial growth factor receptor signaling pathway • embryonic morphogenesis • angiogenesis • protein autophosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • cellular response to vascular endothelial growth factor stimulus • cell migration • positive regulation of MAPK cascade • positive regulation of cell proliferation • positive regulation of cell migration
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE FLT1 222033 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


2321


14254


ENSG00000102755


ENSMUSG00000029648


P17948


P35969

RefSeq (mRNA)


NM_001159920 NM_001160030 NM_001160031 NM_002019


NM_010228

RefSeq (protein)


NP_001153392 NP_001153502 NP_001153503 NP_002010


NP_034358.2 NP_034358

Location (UCSC)

Chr 13: 28.3 – 28.5 Mb

Chr 5: 147.56 – 147.73 Mb

PubMed search

1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3

ENSG00000102755

ENSMUSG00000029648

NM_001159920
NM_001160030
NM_001160031
NM_002019

NP_001153392
NP_001153502
NP_001153503
NP_002010

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Wikipedia

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