FLT4

FLT4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BSJ, 4BSK
Identifiers
Aliases	FLT4, FLT41, LMPH1A, PCL, VEGFR3, FLT-4, VEGFR-3, fms related tyrosine kinase 4
External IDs	MGI: 95561 HomoloGene: 7321 GeneCards: FLT4
Targeted by Drug
cediranib, lenvatinib, linifanib, motesanib, nintedanib, pazopanib, sunitinib, tivozanib, vatalanib
Gene ontology Molecular function • vascular endothelial growth factor-activated receptor activity • transferase activity • nucleotide binding • protein kinase activity • growth factor binding • kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • protein phosphatase binding • ATP binding Cellular component • cytoplasm • integral component of membrane • membrane • receptor complex • plasma membrane • integral component of plasma membrane • extracellular region • nucleus Biological process • regulation of blood vessel remodeling • positive regulation of protein phosphorylation • positive regulation of endothelial cell proliferation • blood vessel morphogenesis • lymphangiogenesis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of protein kinase C signaling • negative regulation of apoptotic process • sprouting angiogenesis • positive regulation of JNK cascade • lymph vessel development • positive regulation of endothelial cell migration • protein phosphorylation • vascular endothelial growth factor receptor signaling pathway • vasculature development • angiogenesis • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • protein autophosphorylation • positive regulation of vascular endothelial growth factor production • peptidyl-tyrosine phosphorylation • cellular response to vascular endothelial growth factor stimulus • positive regulation of MAPK cascade • lung alveolus development • respiratory system process • respiratory gaseous exchange • vascular endothelial growth factor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2324	14257
Ensembl	ENSG00000037280	ENSMUSG00000020357
UniProt	P35916	P35917
RefSeq (mRNA)	NM_002020 NM_182925	NM_008029
RefSeq (protein)	NP_002011 NP_891555	NP_032055.1 NP_032055
Location (UCSC)	Chr 5: 180.6 – 180.65 Mb	Chr 11: 49.61 – 49.65 Mb
PubMed search

4BSJ, 4BSK

2324

14257

ENSG00000037280

ENSMUSG00000020357

P35916

P35917

NM_002020
NM_182925

NM_008029

NP_002011
NP_891555

NP_032055.1
NP_032055

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.

...
Wikipedia