FNDC5

FNDC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LSD
Identifiers
Aliases	FNDC5, FRCP2, irisin, Irisin, fibronectin type III domain containing 5
External IDs	MGI: 1917614 HomoloGene: 17812 GeneCards: FNDC5
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.1 Start 32,862,268 bp End 32,872,482 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 129,136,999 bp End 129,144,593 bp
Gene ontology Molecular function • hormone activity Cellular component • integral component of membrane • extracellular region • peroxisomal membrane • peroxisome • membrane • endoplasmic reticulum • plasma membrane Biological process • response to muscle activity • positive regulation of brown fat cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	252995	384061
Ensembl	ENSG00000160097	ENSMUSG00000001334
UniProt	Q8NAU1	Q8K4Z2
RefSeq (mRNA)	NM_153756 NM_001171940 NM_001171941	NM_027402
RefSeq (protein)	NP_001165411 NP_001165412 NP_715637	NP_081678
Location (UCSC)	Chr 1: 32.86 – 32.87 Mb	Chr 1: 129.14 – 129.14 Mb
PubMed search

4LSD

252995

384061

ENSG00000160097

ENSMUSG00000001334

Q8NAU1

Q8K4Z2

NM_153756
NM_001171940
NM_001171941

NM_027402

NP_001165411
NP_001165412
NP_715637

NP_081678

Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris.

Fibronectin domain-containing protein 5 is a membrane protein comprising a short cytoplasmic domain, a transmembrane segment, and an ectodomain consisting of a ~100 kDa fibronectin type III (FNIII) domain.

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Wikipedia