FUT2

FUT2
Identifiers
Aliases	FUT2, B12QTL1, SE, SEC2, Se2, sej, fucosyltransferase 2
External IDs	MGI: 109374 HomoloGene: 10325 GeneCards: FUT2
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 48,695,971 bp End 48,705,950 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band n/a Start 45,648,591 bp End 45,666,394 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • galactoside 2-alpha-L-fucosyltransferase activity • transferase activity, transferring glycosyl groups • fucosyltransferase activity Cellular component • integral component of membrane • Golgi cisterna membrane • Golgi apparatus • extracellular exosome • membrane Biological process • protein glycosylation • L-fucose catabolic process • fucosylation • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2524	14344
Ensembl	ENSG00000176920	ENSMUSG00000055978
UniProt	Q10981	Q9JL27
RefSeq (mRNA)	NM_001097638 NM_000511	NM_001271993 NM_018876
RefSeq (protein)	NP_000502 NP_001091107	NP_001258922 NP_061364
Location (UCSC)	Chr 19: 48.7 – 48.71 Mb	Chr 19: 45.65 – 45.67 Mb
PubMed search

2524

14344

ENSG00000176920

ENSMUSG00000055978

Q10981

Q9JL27

NM_001097638
NM_000511

NM_001271993
NM_018876

NP_000502
NP_001091107

NP_001258922
NP_061364

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene. It affects the Lewis blood group.

Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.

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Wikipedia