FZD7

FZD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z33
Identifiers
Aliases	FZD7, FzE3, frizzled class receptor 7
External IDs	MGI: 108570 HomoloGene: 20751 GeneCards: FZD7
Gene ontology Molecular function • PDZ domain binding • frizzled binding • signal transducer activity • Wnt-protein binding • protein binding • transmembrane signaling receptor activity • phosphatidylinositol-4,5-bisphosphate binding • G-protein coupled receptor activity • Wnt-activated receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • recycling endosome membrane • endosome • endosome membrane Biological process • negative regulation of cell-substrate adhesion • regulation of catenin import into nucleus • cellular response to retinoic acid • G-protein coupled receptor signaling pathway • non-canonical Wnt signaling pathway • regulation of transcription, DNA-templated • positive regulation of epithelial cell proliferation involved in wound healing • T cell differentiation in thymus • non-canonical Wnt signaling pathway via JNK cascade • negative regulation of ectodermal cell fate specification • somatic stem cell division • positive regulation of JNK cascade • Wnt signaling pathway • stem cell population maintenance • positive regulation of transcription, DNA-templated • multicellular organism development • cell surface receptor signaling pathway • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • neuron differentiation • canonical Wnt signaling pathway • substrate adhesion-dependent cell spreading • positive regulation of phosphorylation • signal transduction • mesenchymal to epithelial transition • Wnt signaling pathway, planar cell polarity pathway • negative regulation of cardiac muscle cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8324	14369
Ensembl	ENSG00000155760	ENSMUSG00000041075
UniProt	O75084	Q61090
RefSeq (mRNA)	NM_003507	NM_008057
RefSeq (protein)	NP_003498	NP_032083.3 NP_032083
Location (UCSC)	Chr 2: 202.03 – 202.04 Mb	Chr 1: 59.48 – 59.49 Mb
PubMed search

4Z33

8324

14369

ENSG00000155760

ENSMUSG00000041075

O75084

Q61090

NM_003507

NM_008057

NP_003498

NP_032083.3
NP_032083

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

FZD7 has been shown to interact with DLG4.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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