GABRA4

GABRA4
Identifiers
Aliases	GABRA4, gamma-aminobutyric acid type A receptor alpha4 subunit
External IDs	MGI: 95616 HomoloGene: 631 GeneCards: GABRA4
Gene ontology Molecular function • ion channel activity • benzodiazepine receptor activity • chloride channel activity • extracellular ligand-gated ion channel activity • GABA-A receptor activity Cellular component • integral component of membrane • GABA-A receptor complex • postsynaptic membrane • membrane • synapse • integral component of plasma membrane • chloride channel complex • cell junction • plasma membrane Biological process • gamma-aminobutyric acid signaling pathway • chloride transmembrane transport • ion transport • regulation of response to drug • central nervous system development • ion transmembrane transport • chloride transport • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2557	14397
Ensembl	ENSG00000109158	ENSMUSG00000029211
UniProt	P48169	Q9D6F4
RefSeq (mRNA)	NM_000809 NM_001204266 NM_001204267	NM_010251
RefSeq (protein)	NP_000800 NP_001191195 NP_001191196	NP_034381.1 NP_034381
Location (UCSC)	Chr 4: 46.92 – 46.99 Mb	Chr 5: 71.57 – 71.66 Mb
PubMed search

2557

14397

ENSG00000109158

ENSMUSG00000029211

P48169

Q9D6F4

NM_000809
NM_001204266
NM_001204267

NM_010251

NP_000800
NP_001191195
NP_001191196

NP_034381.1
NP_034381

Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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