GABRA6

GABRA6
Identifiers
Aliases	GABRA6
External IDs	MGI: 95618 HomoloGene: 20220 GeneCards: GABRA6
Targeted by Drug
gaboxadol, isoguvacine, isonipecotic acid, muscimol, bretazenil, ro-15-4513, flumazenil, bicuculline, picrotoxin, CGS8216
Gene ontology Molecular function • GABA-A receptor activity • ion channel activity • benzodiazepine receptor activity • chloride channel activity • extracellular ligand-gated ion channel activity Cellular component • integral component of membrane • GABA-A receptor complex • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • chloride channel complex • cell junction Biological process • gamma-aminobutyric acid signaling pathway • chloride transmembrane transport • ion transport • ion transmembrane transport • transport • chloride transport • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2559	14399
Ensembl	ENSG00000145863	ENSMUSG00000020428
UniProt	Q16445	P16305
RefSeq (mRNA)	NM_000811	NM_001099641 NM_008068
RefSeq (protein)	NP_000802	NP_001093111.1 NP_032094.2 NP_001093111 NP_032094
Location (UCSC)	Chr 5: 161.55 – 161.7 Mb	Chr 11: 42.31 – 42.32 Mb
PubMed search

2559

14399

ENSG00000145863

ENSMUSG00000020428

Q16445

P16305

NM_000811

NM_001099641
NM_008068

NP_000802

NP_001093111.1
NP_032094.2
NP_001093111
NP_032094

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.

One study has found a genetic variant in the gene to be associated with the personality trait neuroticism.

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Wikipedia