GALC
| Galactosylceramidase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.2.1.46 | ||||||||
| CAS number | 9027-89-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
| GALC | |||||||||||||||||
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| Aliases | GALC, entrez:2581, galactosylceramidase | ||||||||||||||||
| External IDs | OMIM: 606890 MGI: 95636 HomoloGene: 124 GeneCards: GALC | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 14: 87.84 – 87.99 Mb | Chr 12: 98.2 – 98.26 Mb | |||||||||||||||
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Galactosylceramidase (or galactocerebrosidase) is an enzyme that in humans is encoded by the GALC gene. Galactosylceramidase is an enzyme which removes galactose from ceramide derivatives ().
Galactosylceramidase is a lysosomal protein which hydrolyzes the galactose ester bonds of , galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy.
NM_000153
NM_001037525
NM_001201401
NM_001201402
NP_000144
NP_001188330
NP_001188331
...
Wikipedia