GATA3

GATA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HC7, 4HC9, 4HCA
Identifiers
Aliases	GATA3, HDR, HDRS, GATA binding protein 3
External IDs	MGI: 95663 HomoloGene: 1550 GeneCards: GATA3
Gene ontology Molecular function • RNA polymerase II transcription factor binding • RNA polymerase II regulatory region sequence-specific DNA binding • HMG box domain binding • chromatin binding • metal ion binding • RNA polymerase II core promoter sequence-specific DNA binding • DNA binding • enhancer sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription regulatory region DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • nucleic acid binding transcription factor activity • interleukin-2 receptor binding • core promoter sequence-specific DNA binding • transcription regulatory region sequence-specific DNA binding • protein dimerization activity • E-box binding • protein binding • zinc ion binding • transcription factor binding • transcription coactivator activity Cellular component • nucleus • transcription factor complex • nuclear chromatin • nucleoplasm Biological process • negative regulation of cell proliferation • regulation of establishment of cell polarity • ureteric bud formation • negative regulation of cell cycle • thymic T cell selection • response to ethanol • positive regulation of T cell differentiation • erythrocyte differentiation • positive regulation of interleukin-5 secretion • inner ear morphogenesis • cell maturation • regulation of histone H3-K27 methylation • cardiac right ventricle morphogenesis • phosphatidylinositol 3-kinase signaling • norepinephrine biosynthetic process • ear development • homeostasis of number of cells • sympathetic nervous system development • T-helper 2 cell differentiation • regulation of cellular response to X-ray • cell fate determination • post-embryonic development • cellular response to BMP stimulus • mesonephros development • neuron differentiation • regulation of neuron apoptotic process • signal transduction • cellular response to cytokine stimulus • cellular response to interleukin-4 • T cell receptor signaling pathway • neuron migration • positive regulation of interleukin-5 production • regulation of CD4-positive, alpha-beta T cell differentiation • parathyroid gland development • negative regulation of DNA demethylation • positive regulation of interleukin-4 production • negative regulation of mammary gland epithelial cell proliferation • regulation of transcription from RNA polymerase II promoter • thymus development • nervous system development • otic vesicle development • regulation of transcription, DNA-templated • positive regulation of T-helper 2 cell cytokine production • regulation of nephron tubule epithelial cell differentiation • positive regulation of thyroid hormone generation • lymphocyte migration • negative regulation of interleukin-2 production • regulation of neuron projection development • uterus development • axon guidance • mesenchymal to epithelial transition • negative regulation of cell proliferation involved in mesonephros development • aortic valve morphogenesis • cellular response to tumor necrosis factor • negative regulation of fat cell differentiation • anatomical structure morphogenesis • cellular response to interferon-alpha • negative regulation of transcription, DNA-templated • T cell differentiation • response to virus • negative regulation of endothelial cell apoptotic process • regulation of cytokine biosynthetic process • innate immune response • canonical Wnt signaling pathway involved in metanephric kidney development • positive regulation of transcription regulatory region DNA binding • positive regulation of endothelial cell migration • positive regulation of interleukin-13 production • in utero embryonic development • negative regulation of interferon-gamma production • humoral immune response • developmental growth • kidney development • positive regulation of ureteric bud formation • positive regulation of gene expression • interferon-gamma secretion • mast cell differentiation • positive regulation of interleukin-13 secretion • positive regulation of histone H3-K9 acetylation • positive regulation of cell differentiation • negative regulation of transcription from RNA polymerase II promoter • male gonad development • nephric duct morphogenesis • ventricular septum development • positive regulation of cytokine production • lens development in camera-type eye • negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation • transcription, DNA-templated • negative regulation of gene expression • parathyroid hormone secretion • nephric duct formation • immune system process • negative regulation of inflammatory response • pharyngeal system development • embryonic organ development • response to estrogen • blood coagulation • negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation • positive regulation of signal transduction • ureter maturation • positive regulation of histone H3-K14 acetylation • positive regulation of transcription, DNA-templated • response to gamma radiation • cell morphogenesis • embryonic hemopoiesis • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell motility • pro-T cell differentiation • TOR signaling • type IV hypersensitivity • defense response • interleukin-4 secretion • regulation of histone H3-K4 methylation • renal system development • positive regulation of protein kinase B signaling • cell activation • response to drug • chromatin remodeling • T cell differentiation in thymus • cochlea development • transcription from RNA polymerase II promoter • protein deubiquitination • anatomical structure formation involved in morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2625	14462
Ensembl	ENSG00000107485	ENSMUSG00000015619
UniProt	P23771	P23772
RefSeq (mRNA)	NM_001002295 NM_002051	NM_008091
RefSeq (protein)	NP_001002295 NP_002042	NP_032117.1 NP_032117
Location (UCSC)	Chr 10: 8.05 – 8.08 Mb	Chr 2: 9.86 – 9.89 Mb
PubMed search

4HC7, 4HC9, 4HCA

2625

14462

ENSG00000107485

ENSMUSG00000015619

P23771

P23772

NM_001002295
NM_002051

NM_008091

NP_001002295
NP_002042

NP_032117.1
NP_032117

Transcription factor GATA-3 is a protein that in humans is encoded by the GATA3 gene.

GATA-3 belongs to the GATA family of transcription factors. It regulates luminal epithelial cell differentiation in the mammary gland. The protein contains two GATA-type zinc fingers and is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA-3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells, and induces the differentiation of Th0 cells towards this Th2 cell subtype while suppressing their differentiation towards Th1 cells. It is hypothesised that GATA-3 may play tissue-specific roles. It has been suggested that GATA-3 is regulated in CD4+ T cells at a transcriptional level through the IL-4 receptor, as well as translationally through T cell receptor signaling.

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