GGPS1

GGPS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q80
Identifiers
Aliases	GGPS1, GGPPS, GGPPS1, geranylgeranyl diphosphate synthase 1
External IDs	MGI: 1341724 HomoloGene: 31267 GeneCards: GGPS1
EC number	2.5.1.1
Gene ontology Molecular function • transferase activity • farnesyltranstransferase activity • protein binding • metal ion binding • dimethylallyltranstransferase activity • geranyltranstransferase activity • identical protein binding Cellular component • cytoplasm • cytosol Biological process • cholesterol biosynthetic process • farnesyl diphosphate biosynthetic process • geranyl diphosphate biosynthetic process • geranylgeranyl diphosphate biosynthetic process • isoprenoid biosynthetic process • isoprenoid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9453	14593
Ensembl	ENSG00000152904	ENSMUSG00000021302
UniProt	O95749	Q9WTN0
RefSeq (mRNA)	NM_001037277 NM_001037278 NM_004837	NM_010282
RefSeq (protein)	NP_001032354 NP_001032354.1	NP_034412.1 NP_001318048 NP_001318105 NP_001318106 NP_001318107 NP_001318109 NP_034412
Location (UCSC)	Chr 1: 235.33 – 235.34 Mb	Chr 13: 14.05 – 14.06 Mb
PubMed search

2Q80

9453

14593

ENSG00000152904

ENSMUSG00000021302

O95749

Q9WTN0

NM_001037277
NM_001037278
NM_004837

NM_010282

NP_001032354
NP_001032354.1

NP_001318109
NP_034412

Geranylgeranyl pyrophosphate synthase is an enzyme that in humans is encoded by the GGPS1 gene.

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

...
Wikipedia