GLIPR1

GLIPR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q2R, 3Q2U
Identifiers
Aliases	GLIPR1, CRISP7, GLIPR, RTVP1, GLI pathogenesis related 1
External IDs	MGI: 1920940 HomoloGene: 21357 GeneCards: GLIPR1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q21.2 Start 75,480,680 bp End 75,503,853 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D2 Start 111,985,448 bp End 112,002,631 bp
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11010	73690
Ensembl	ENSG00000139278	ENSMUSG00000056888
UniProt	P48060	Q9CWG1
RefSeq (mRNA)	NM_006851	NM_028608
RefSeq (protein)	NP_006842	NP_082884
Location (UCSC)	Chr 12: 75.48 – 75.5 Mb	Chr 12: 111.99 – 112 Mb
PubMed search

3Q2R, 3Q2U

11010

73690

ENSG00000139278

ENSMUSG00000056888

P48060

Q9CWG1

NM_006851

NM_028608

NP_006842

NP_082884

Glioma pathogenesis-related protein 1 is a protein that in humans is encoded by the GLIPR1 gene.

This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family.

The previous finding of RTVP1 (GLIPR1) as a p53 target gene with tumor suppressor functions prompted the researches to initiate a genome-wide sequence homology search for RTVP1/GLIPR1-like (GLIPR1L) genes. p53, the tumor suppressor gene is the most commonly mutated gene in human cancer. Mutation in p53 gene can lead to cellular malfunctions such as malignant growth and metsastatis. Human GLIPR1, was initially identified in human glioblastoma and was called as GLIPR1 (glioma pathogenesis-related protein 1) or RTVP1 (related to testes-specific, vespid, and pathogenesis protein 1). Furthermore, it was identified as a marker of myelomocytic differentiation in macrophage. RTVP-1 cluster proteins share significant sequence homology with the members of (PR ) superfamily and CRISP Family proteins.

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Wikipedia