GLRX5

GLRX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MMZ, 2WUL
Identifiers
Aliases	GLRX5, C14orf87, FLB4739, GRX5, PR01238, PRO1238, PRSA, SIDBA3, SPAHGC, glutaredoxin 5
External IDs	MGI: 1920296 HomoloGene: 31984 GeneCards: GLRX5
Gene ontology Molecular function • protein disulfide oxidoreductase activity • electron carrier activity • iron-sulfur cluster binding • metal ion binding • 2 iron, 2 sulfur cluster binding • disulfide oxidoreductase activity • protein binding Cellular component • neuronal cell body • dendrite • nucleus • mitochondrion • mitochondrial matrix Biological process • hemopoiesis • oxidation-reduction process • cell redox homeostasis • protein lipoylation • small molecule metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51218	73046
Ensembl	ENSG00000182512	ENSMUSG00000021102
UniProt	Q86SX6	Q80Y14
RefSeq (mRNA)	NM_016417	NM_028419
RefSeq (protein)	NP_057501	NP_082695
Location (UCSC)	Chr 14: 95.53 – 95.54 Mb	Chr 12: 105.03 – 105.04 Mb
PubMed search

2MMZ, 2WUL

51218

73046

ENSG00000182512

ENSMUSG00000021102

Q86SX6

Q80Y14

NM_016417

NM_028419

NP_057501

NP_082695

Glutaredoxin 5, also known as GLRX5, is a protein which in humans is encoded by the GLRX5 gene located on chromosome 14. This gene encodes a protein, which is evolutionarily conserved. It is involved in the biogenesis of iron- sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.

The GLRX5 gene contains 2 exons and encodes for a protein that is 13 kDa in size. The protein is highly expressed in erythroid cells.Crystal structure of the GLRX5 protein reveals that the protein likely exists as a tetramer with two Fe-S clusters buried in the interior.

...
Wikipedia