GNS (gene)

GNS
Identifiers
Aliases	GNS, G6S, glucosamine (N-acetyl)-6-sulfatase
External IDs	MGI: 1922862 HomoloGene: 1568 GeneCards: GNS
Gene ontology Molecular function • sulfuric ester hydrolase activity • protein binding • catalytic activity • hydrolase activity • metal ion binding • N-acetylglucosamine-6-sulfatase activity Cellular component • lysosome • lysosomal lumen • extracellular exosome • extracellular region • azurophil granule lumen • ficolin-1-rich granule lumen Biological process • metabolic process • glycosaminoglycan catabolic process • keratan sulfate catabolic process • glycosaminoglycan metabolic process • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2799	75612
Ensembl	ENSG00000135677	ENSMUSG00000034707
UniProt	P15586	Q8BFR4
RefSeq (mRNA)	NM_002076	NM_029364
RefSeq (protein)	NP_002067 NP_002067.1	NP_083640.1 NP_083640
Location (UCSC)	Chr 12: 64.71 – 64.76 Mb	Chr 10: 121.37 – 121.4 Mb
PubMed search

N-acetylglucosamine-6-sulfatase
Identifiers
EC number	3.1.6.14
CAS number	60320-99-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

2799

75612

ENSG00000135677

ENSMUSG00000034707

P15586

Q8BFR4

NM_002076

NM_029364

NP_002067
NP_002067.1

NP_083640.1
NP_083640

N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase is an enzyme that in humans is encoded by the GNS gene. This enzyme is deficient in Sanfilippo Syndrome type IIId. This enzyme catalyses the following chemical reaction:

N-acetylglucosamine-6-sulfatase is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate.

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Wikipedia