GPR177

WLS
Identifiers
Aliases	WLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator
External IDs	MGI: 1915401 HomoloGene: 11779 GeneCards: WLS
Gene ontology Molecular function • mu-type opioid receptor binding • signal transducer activity • protein binding • Wnt-protein binding Cellular component • integral component of membrane • endocytic vesicle membrane • endosome • Golgi apparatus • early endosome membrane • membrane • plasma membrane • dendrite membrane • trans-Golgi network • early endosome • dendrite cytoplasm • extracellular exosome • cytoplasmic vesicle membrane • endoplasmic reticulum membrane • cytoplasmic vesicle • Golgi membrane • endoplasmic reticulum Biological process • exocrine pancreas development • positive regulation of canonical Wnt signaling pathway • positive regulation of Wnt protein secretion • mesoderm formation • hindbrain development • multicellular organism development • positive regulation of Wnt signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • intracellular protein transport • anterior/posterior axis specification • midbrain development • Wnt signaling pathway • Wnt protein secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79971	68151
Ensembl	ENSG00000116729	ENSMUSG00000028173
UniProt	Q5T9L3	Q6DID7
RefSeq (mRNA)	NM_001002292 NM_001193334 NM_024911	NM_026582
RefSeq (protein)	NP_001002292 NP_001180263 NP_079187	NP_080858.3 NP_080858
Location (UCSC)	Chr 1: 68.1 – 68.23 Mb	Chr 3: 159.84 – 159.94 Mb
PubMed search

79971

68151

ENSG00000116729

ENSMUSG00000028173

Q5T9L3

Q6DID7

NM_001002292
NM_001193334
NM_024911

NM_026582

NP_001002292
NP_001180263
NP_079187

NP_080858.3
NP_080858

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene that encodes a receptor for Wnt proteins in Wnt-secreting cells.

Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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