GPX4

GPX4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GS3, 2OBI
Identifiers
Aliases	GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx, SMDS, glutathione peroxidase 4
External IDs	MGI: 104767 HomoloGene: 134384 GeneCards: GPX4
Gene ontology Molecular function • glutathione peroxidase activity • phospholipid-hydroperoxide glutathione peroxidase activity • oxidoreductase activity • peroxidase activity Cellular component • cytosol • extracellular exosome • cytoplasm • nucleus • nucleoplasm • mitochondrion Biological process • response to oxidative stress • multicellular organism development • lipoxygenase pathway • oxidation-reduction process • phospholipid metabolic process • cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2879	625249
Ensembl	ENSG00000167468	ENSMUSG00000075706
UniProt	P36969	Q91XR9 O70325
RefSeq (mRNA)	NM_002085 NM_001039847 NM_001039848	NM_001037741 NM_008162
RefSeq (protein)	NP_001034936 NP_001034937 NP_002076	NP_001032830.2 NP_001032830.2 NP_032188.3
Location (UCSC)	Chr 19: 1.1 – 1.11 Mb	Chr 10: 80.05 – 80.06 Mb
PubMed search

2GS3, 2OBI

2879

625249

ENSG00000167468

ENSMUSG00000075706

P36969

Q91XR9
O70325

NM_002085
NM_001039847
NM_001039848

NM_001037741
NM_008162

NP_001034936
NP_001034937
NP_002076

NP_001032830.2
NP_001032830.2
NP_032188.3

Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation.

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Wikipedia