GR-113808

GR-113808

Identifiers
IUPAC name 1-(2-methylsulfonylaminoethyl-4-piperidinyl)methyl-1-methyl-1H-indole-3-carboxylate
CAS Number	144625-51-4
PubChem CID	119376
IUPHAR/BPS	247
ChemSpider	106623
Chemical and physical data
Formula	C19H27N3O4S
Molar mass	393.499 g/mol
3D model (Jmol)	Interactive image
SMILES c13ccccc3c(cn1C)C(=O)OCC(CC2)CCN2CCNS(=O)(C)=O
InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3 Key:MOZPSIXKYJUTKI-UHFFFAOYSA-N

GR-113808 is a drug which acts as a potent and selective 5-HT₄ serotonin receptor antagonist. It is used in researching the roles of 5-HT₄ receptors in various processes, and has been used to test some of the proposed therapeutic effects of selective 5-HT₄ agonists, such as for instance blocking the nootropic effects of 5-HT₄ agonists, and worsening the respiratory depression produced by opioid analgesic drugs, which appears to be partly 5-HT₄ mediated and can be counteracted by certain 5-HT₄ agonists.