GRLF1

ARHGAP35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K85, 3C5H, 3FK2
Identifiers
Aliases	ARHGAP35, GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP, Rho GTPase activating protein 35
External IDs	MGI: 1929494 HomoloGene: 35136 GeneCards: ARHGAP35
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription corepressor activity • GTP binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • phospholipid binding • GTPase activator activity Cellular component • cytoplasm • cytosol • actin cytoskeleton • nucleus • cytoskeleton • cell projection • plasma membrane • membrane • ciliary basal body Biological process • regulation of transcription, DNA-templated • negative regulation of Rho protein signal transduction • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • neural tube closure • regulation of cell shape • forebrain development • camera-type eye development • negative regulation of transcription, DNA-templated • regulation of small GTPase mediated signal transduction • signal transduction • negative regulation of vascular permeability • positive regulation of GTPase activity • small GTPase mediated signal transduction • axon guidance • axonal fasciculation • regulation of actin polymerization or depolymerization • positive regulation of neuron projection development • cell migration • central nervous system neuron axonogenesis • mammary gland development • establishment or maintenance of actin cytoskeleton polarity • cellular response to extracellular stimulus • regulation of actin cytoskeleton organization • wound healing, spreading of cells • positive regulation of cilium assembly • regulation of axonogenesis • neuron projection guidance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2909	232906
Ensembl	ENSG00000160007	ENSMUSG00000058230
UniProt	Q9NRY4	Q91YM2
RefSeq (mRNA)	NM_004491 NM_024342	NM_172739
RefSeq (protein)	NP_004482	NP_766327.3 NP_766327
Location (UCSC)	Chr 19: 46.92 – 47.01 Mb	Chr 7: 16.49 – 16.61 Mb
PubMed search

2K85, 3C5H, 3FK2

2909

232906

ENSG00000160007

ENSMUSG00000058230

Q9NRY4

Q91YM2

NM_004491
NM_024342

NM_172739

NP_004482

NP_766327.3
NP_766327

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.

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