GRM1

GRM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KS9, 4OR2
Identifiers
Aliases	GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1
External IDs	MGI: 1351338 HomoloGene: 649 GeneCards: GRM1
Gene ontology Molecular function • glutamate receptor activity • G-protein coupled receptor activity • signal transducer activity • protein binding • neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Cellular component • integral component of membrane • G-protein coupled receptor dimeric complex • postsynaptic density of dendrite • membrane • G-protein coupled receptor homodimeric complex • plasma membrane • integral component of plasma membrane • dendrite • neuron projection • nucleus • presynaptic membrane Biological process • cellular response to electrical stimulus • G-protein coupled glutamate receptor signaling pathway • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • regulation of MAPK cascade • regulation of sensory perception of pain • locomotory behavior • dimeric G-protein coupled receptor signaling pathway • activation of MAPKK activity • activation of MAPK activity • sensory perception of pain • signal transduction • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • regulation of postsynaptic cytosolic calcium ion concentration • chemical synaptic transmission, postsynaptic Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2911	14816
Ensembl	ENSG00000152822	ENSMUSG00000019828
UniProt	Q13255	P97772
RefSeq (mRNA)	NM_000838 NM_001114329 NM_001278064 NM_001278065 NM_001278066 NM_001278067	NM_001114333 NM_016976
RefSeq (protein)	NP_000829 NP_001264993 NP_001264994 NP_001264995 NP_001264996	NP_001107805 NP_058672
Location (UCSC)	Chr 6: 146.03 – 146.44 Mb	Chr 10: 10.69 – 11.08 Mb
PubMed search

3KS9, 4OR2

2911

14816

ENSG00000152822

ENSMUSG00000019828

Q13255

P97772

NM_001278067

NM_001114333
NM_016976

NP_000829
NP_001264993
NP_001264994
NP_001264995
NP_001264996

NP_001107805
NP_058672

The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 (mGluR1) protein.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined.

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Wikipedia