GYPB

GYPB
Identifiers
Aliases	GYPB, CD235b, GPB, GPB.NY, GYPHe.NY, GpMiIII, HGpMiIII, HGpMiVI, HGpMiX, MNS, PAS-3, SS, GYP, glycophorin B (MNS blood group)
External IDs	GeneCards: GYPB
Gene ontology Molecular function • protein binding Cellular component • integral component of plasma membrane • membrane • plasma membrane • integral component of membrane Biological process • leukocyte migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2994	n/a
Ensembl	ENSG00000250361	n/a
UniProt	P06028	n/a
RefSeq (mRNA)	NM_001304382 NM_002100	n/a
RefSeq (protein)	NP_001291311 NP_002091	n/a
Location (UCSC)	Chr 4: 144 – 144.02 Mb	n/a
PubMed search		n/a

2994

n/a

ENSG00000250361

n/a

P06028

n/a

NM_001304382
NM_002100

n/a

NP_001291311
NP_002091

n/a

Glycophorin B (MNS blood group) (gene designation GYPB) also known as sialoglycoprotein delta and SS-active sialoglycoprotein is a protein which in humans is encoded by the GYPB gene. GYPB has also recently been designated CD235b (cluster of differentiation 235b).

Glycophorin A (GYPA) and B (GYPB; this protein) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups respectively. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include the Miltenberger (Mi) complex and several isoforms of Stones (St^a); also Dantu, Sat, Henshaw (He or MNS6), Mg and deletion variants En^a, S-s-U- and M^k. Most of these are the result of gene recombinations between GYPA and GYPB.

The gene is located on the long arm of chromosome 4 (4q28-q31) and has 5 exons. It was first sequenced in 1987 the peptide sequence of 72 amino acids having been determined earlier that year.

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Wikipedia