G protein-coupled receptor kinase 2

GRK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PNK, 1BAK, 3CIK, 3KRW, 3KRX, 3V5W, 4MK0, 5HE1
Identifiers
Aliases	GRK2, BARK1, BETA-ARK1, ADRBK1, G protein-coupled receptor kinase 2
External IDs	MGI: 87940 HomoloGene: 1223 GeneCards: GRK2
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.2 Start 67,266,410 bp End 67,286,556 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band n/a Start 4,286,001 bp End 4,306,222 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • Edg-2 lysophosphatidic acid receptor binding • protein kinase activity • nucleotide binding • G-protein coupled receptor kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • alpha-2A adrenergic receptor binding • ATP binding • beta-adrenergic receptor kinase activity Cellular component • cytoplasm • cytosol • membrane • plasma • cilium Biological process • G-protein coupled acetylcholine receptor signaling pathway • G-protein coupled receptor signaling pathway • cardiac muscle contraction • phosphorylation • regulation of the force of heart contraction • viral genome replication • negative regulation of striated muscle contraction • positive regulation of catecholamine secretion • receptor internalization • tachykinin receptor signaling pathway • protein phosphorylation • heart development • peptidyl-serine phosphorylation • viral entry into host cell • desensitization of G-protein coupled receptor protein signaling pathway • peptidyl-threonine phosphorylation • negative regulation of the force of heart contraction by chemical signal • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	156	110355
Ensembl	ENSG00000173020	ENSMUSG00000024858
UniProt	P25098	Q99MK8
RefSeq (mRNA)	NM_001619	NM_001290818 NM_130863
RefSeq (protein)	NP_001610	NP_001277747 NP_570933
Location (UCSC)	Chr 11: 67.27 – 67.29 Mb	Chr 11: 4.29 – 4.31 Mb
PubMed search

4PNK, 1BAK, 3CIK, 3KRW, 3KRX, 3V5W, 4MK0, 5HE1

156

110355

ENSG00000173020

ENSMUSG00000024858

P25098

Q99MK8

NM_001619

NM_001290818
NM_130863

NP_001610

NP_001277747
NP_570933

Beta adrenergic receptor kinase (also referred to as βARK or BARK) is a serine/threonine intracellular kinase. It is activated by PKA and its target is the beta adrenergic receptor. It is one method by which the cell will desensitize itself from epinephrine overstimulation.

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Wikipedia