Gamma-glutamyl carboxylase

GGCX
Identifiers
Aliases	GGCX, VKCFD1, gamma-glutamyl carboxylase
External IDs	OMIM: 137167 MGI: 1927655 HomoloGene: 639 GeneCards: GGCX
Targeted by Drug
anisindione
Gene ontology Molecular function • gamma-glutamyl carboxylase activity • lyase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • peptidyl-glutamic acid carboxylation • cellular protein modification process • blood coagulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2677	56316
Ensembl	ENSG00000115486	n/a
UniProt	P38435	Q9QYC7
RefSeq (mRNA)	NM_000821 NM_001142269 NM_001311312	NM_019802
RefSeq (protein)	NP_000812 NP_001135741 NP_001298241	NP_062776.1 NP_062776
Location (UCSC)	Chr 2: 85.54 – 85.56 Mb	Chr 6: 72.41 – 72.43 Mb
PubMed search

2677

56316

ENSG00000115486

n/a

P38435

Q9QYC7

NM_000821
NM_001142269
NM_001311312

NM_019802

NP_000812
NP_001135741
NP_001298241

NP_062776.1
NP_062776

Gamma-glutamyl carboxylase is an enzyme that in humans is encoded by the GGCX gene, located on chromosome 2 at 2p12.

Gamma-glutamyl carboxylase is an enzyme that catalyzes the posttranslational modification of vitamin K-dependent proteins. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Most gla domain-containing proteins depend on this carboxylation reaction for posttranslational modification. In humans, the gamma-glutamyl carboxylase enzyme is most highly expressed in the liver.

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Wikipedia