Gastricsin

PGC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AVF, 1HTR
Identifiers
Aliases	PGC, PEPC, PGII, gastricsin, progastricsin (pepsinogen C), progastricsin
External IDs	MGI: 98909 HomoloGene: 55669 GeneCards: PGC
Gene ontology Molecular function • peptidase activity • hydrolase activity • aspartic-type endopeptidase activity Cellular component • extracellular region • extracellular exosome • extracellular space Biological process • positive regulation of antibacterial peptide production • digestion • protein catabolic process • proteolysis • autophagy Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5225	109820
Ensembl	ENSG00000096088	ENSMUSG00000023987
UniProt	P20142	Q9D7R7
RefSeq (mRNA)	NM_002630 NM_001166424	NM_025973
RefSeq (protein)	NP_001159896 NP_002621	NP_080249.2 NP_080249
Location (UCSC)	Chr 6: 41.74 – 41.75 Mb	Chr 17: 47.73 – 47.73 Mb
PubMed search

1AVF, 1HTR

5225

109820

ENSG00000096088

ENSMUSG00000023987

P20142

Q9D7R7

NM_002630
NM_001166424

NM_025973

NP_001159896
NP_002621

NP_080249.2
NP_080249

Gastricsin also known as pepsinogen C is an enzyme that in humans is encoded by the PGC gene.

Gastricsin is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself.

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